应用肌电图评估托吡酯治疗面肌痉挛的效果

Electromyogram in assessing the effect of topiramate therapy for facial spasm

目的:观察托吡酯治疗面肌痉挛的临床疗效及不良反应,并使用肌电图对面肌痉挛的改善情况做出评定。方法:北京友谊医院神经内科2001-03/2002-03收治43例面肌痉挛患者,使用托吡酯治疗8周,治疗前后分别采用Cohn,Albert标准判定面肌痉挛的程度,根据Cohn,Albert评级的改变评价托吡酯治疗面肌痉挛的临床疗效,并同时检查肌电图,记录托吡酯治疗的不良反应。结果:托吡酯治疗面肌痉挛的有效率为86%(37/43),且与肌电图的改善相一致。不良反应多出现在加量期,随服药时间的延长而消失。结论:托吡酯治疗面肌痉挛安全有效。

AIM:To study the clinical effects and adverse reaction after facial spasm treated with topiramate,and assess the improvement of facial spasm by using electromyogram(EMG). METHODS:Forty three patients with facial spasm were selected from the Department of Neurology,Beijing Frendship Hospital Affiliated to Capital University of Medical Sciences during March 2001 and March 2002.All the patients were treated with topiramate for 8 weeks.The degree of facial spasm was assessed by the standard of Cohn,Albert,and the clinical effects of topiramate in treating facial spasm were evaluated according to the changes of Cohn and Albert scores.Meanwhile,the EMG was examined and adverse reaction after treatment with topiramate was recorded. RESULTS:The effective rate of topiramate in treating facial spasm was 86%(37/43),which was in accordance with that of improvement of EMG.Most adverse reaction appeared in the drug increase period and disappeared with the delayed therapy. CONCLUSION:The topiramate is effective and safe in the treatment of facial spasm.