63例肺癌患者呼吸阻力和弥散功能测定及意义探讨

Measurement of Respiratory Resistance and Diffusion Capacity in 63 Lung Cancer Patients and Its Clinical Significance Investigation

目的 :探讨脉冲振荡法 (IOS)对肺癌患者呼吸阻力和弥散功能的测定及临床意义。方法 :对 33例健康对照组 (A组 )、 6 3例肺癌研究组患者测定肺通气功能、弥散功能及IOS指标 ,对所有指标进行t检验。结果 :肺癌患者共振频率 (Fres) ,外周阻力 (Rpe)明显增加 ,通气功能 ,弥散功能减低 ,两型肺癌脉冲频率在 5Hz、2 0HZ时的气道粘性阻力也 (R5,R2 0 )增加 ,与健康组之间差异非常显著 ,中央型 (B组 )和周围型 (C组 )肺癌之间无显著性差异。结论 :肺癌的Rpe、R5、R2 0 和Fres均有增加 ,肺癌患者的呼吸组力在鉴别肺癌的类型上无意义 ,但对了解肺癌患者肺功能损害增加了新的内容。

Objective:To study the clinical significance of the respiratory resistance and diffusion capacity in lung cancer patients.Method:The ventilation function,diffusion capacity and respiratory resistance by IOS were measured in 33 normal subjects and 63 patients with lung cancer,and the results were examined by T test.Result:The total airway resistance(R 5),central airway resistance(R 20.)and resonant frequency,peripheral resistance increased significantly in patients with lung cancer compared with normal subjects,but there were no significant difference between central and peripheral lung cancer.Conclusion:The respiration resistance of the patients increased,but it is of no value in distinguishing the type of lung cancer.