甲醛吸入对小鼠不同组织器官谷胱苷肽水平的影响

Effect of Formaldehyde Inhalation on Glutathione Level in Various Organs of Mice

目的 探讨经不同浓度甲醛吸入对小鼠不同组织器官的氧化损伤作用及其分子机理。方法 用 1m g/ m3和 3m g/ m3的甲醛气体对小鼠进行染毒处理 ,测定吸入甲醛后 5种器官 (脑、心、肝、肺、肾 )的谷胱苷肽 (GSH)含量。结果 吸入 1mg/ m3甲醛的小鼠 ,心、肺、肝、肾的 GSH含量明显下降 (P<0 .0 1,P<0 .0 5 ) ,其中心最为严重 ;吸入 3mg/ m3甲醛的小鼠 ,所试全部器官的 GSH水平均显著下降 (P<0 .0 0 1,P<0 .0 1,P<0 .0 5 ) ,脑、心、肾最为严重 ,肺次之 ,肝较轻。结论 气态甲醛对机体的各组织器官均有氧化损伤作用 ,是一种全身性毒物。

Objective To explore oxidation damage effect of different levels of formaldehyde inhalation on various organs of mice and its molecular mechanism. Methods The mice were treated with 1 mg/m3 and 3 mg/m3 of gaseous formaldehyde. Then the content of glutathione(GSH) in five organs(brain, lung, heart, liver, kidney) were measured. Results The results showed that formaldehyde inhalation caused obvious decrease of GSH content in various organs. Especially in high concentration(3 mg/m3) group, GSH level in all the tested organs were decreased significantly(P<0.001, P<0.01, P<0.05). Conclusion It is suggested that formaldehyde inhalation induces oxidation damage on various organs. It is a systematic toxin.