异甘草酸镁对大鼠四氯化碳慢性肝损伤的治疗作用

Therapeutic effects of magnesium isoglycyrrhizinate on chronic liver injury induced by CCl_4 in rats

目的 :观察异甘草酸镁 (MgIG )治疗大鼠慢性四氯化碳 (CCl4 )肝损伤的疗效。方法 :12 0只SD大鼠随机分成正常对照组 ,模型对照组 ,阳性对照组和MgIG 15 ,30 ,6 0mg·kg- 1治疗组 6组。除正常对照组外 ,所有动物皮下注射 2 5 %CCl4 橄榄油液 2mL·kg- 1,每周 2次 ,连续 13wk。wk 5起 ,相应予生理盐水 ,生理盐水 ,复方甘草甜素注射液 ,MgIG 15 ,30 ,6 0mg·kg- 1,ip ,qd ,连续至 13wk。结果 :与模型对照组相比 ,MgIG能显著降低慢性CCl4肝损伤大鼠血清转氨酶、唾液酸、透明质酸以及血浆一氧化氮、肝组织羟脯氨酸含量 ,且呈剂量依赖性。另外 ,MgIG可减轻肝组织炎症及纤维化。结论 :MgIG对大鼠CCl4

AIM: To observe therapeutic effects of magnesium isoglycyrrhizinate (MgIG) on chronic liver injury induced by CCl_4 in rats. METHODS: One hundred and twenty SD rats were randomly divided into six groups (n=20,each group): normal control group, model control group, positive control group and three MgIG treatment groups with MgIG 15, 30 and 60 mg·kg^(-1). Except for normal control group, each group was given CCl_4 oliver oil (25 %,W/V) 2mL·kg^(-1), sc, two times a week for 13 wk. From wk 5 to wk 13, they administered saline, saline, stronger neo-minophagen C injection (SNMC) 30 mL·kg^(-1), MgIG 15, 30, 60 mg·kg^(-1),ip, qd, respectively. RESULTS: Compared with the model control group, MgIG could dose-dependently prevent from the increase of aminotransferase activity caused by CCl_4, decrease concentration of serum sialic acid, hyaluronic acid, inhibit level of plasma nitric oxide and liver hydroxyproline. In addition, MgIG could alleviate degree of inflammatory and fibrosis. CONCLUSION: MgIG was effective in treating chronic liver injury induced by CCl_4 in rats.