系统性红斑狼疮红细胞免疫功能的研究

RED CELL IMMUNE IN SYSTEMIC LUPUS ERYTHEMATOSUS

测定25例活动期和22例缓解期系统性红斑狼疮病人红细胞免疫功能。结果发现,活动期病人红细胞C_3受体活性明显低于对照组(P<0.01)和缓解期病人(P<0.01。活动期病人红细胞表面免疫复合物明显高于对照组(P<0.01)和缓解期病人(P<0.01)。活动期病人红细胞免疫粘附促进因子活性明显低于正常对照组(P<0.01),而红细胞免疫粘附抑制因子活性则明显高于对照组(P<0.01)。此外,还发现系统性红斑狼疮病人红细胞C-3b受体活性与外周血淋巴细胞产生白细胞介素2活性以及与血C_3呈正相关,与血清γ球蛋白呈负相关。结果提示,红细胞C_3b受体活性的降低。可能是导致系统性红斑狼疮发病的因素之一。红细胞免疫功能状态对判断本病的活动及转归,可能有一定的参考意义。

Red cell immune functions were measured in 25 active and 22 remissive systemic lupus erythematosus (SLE) patients. The activity of erythrocyte C3b receptor (E-C3bR) in active SLE was significantly lower than that of normal controls ( P<0.01 ) and that of remissive SLE ( P<0.01 ) . The level of immune complexes on erythrocytes (E-IC) in active SLE increased more significantly than that of normal controls ( P<0.01 ) and remissive SLE ( p<0.01 ) .The erythrocyte immune adherence enhancing factor (EIAEF) in active SLE was significantly lower than that of normal controls ( p<0.01 ). The activity of erythrocyte immune adherence inhibiting factor (EIAIF) in active SLE was significantly higher than that of normal controls ( P<0.01 ) . E-C3bR activity in SLE was negatively correlated with the level of gamma globin, positively correlated with the level of C3 and positively correlated with interleukin-2 (IL-2) activity. These results indicate that deficiency of E-C3bR may play a role in the pathogenesis of SLE and the tests studies of red cell immune function may well serve as a diagnostic criteria for the various stages in the disease course of SLE.