迅速发展型鼻咽癌——31例临床病理分析

RAPIDLY PROGRESSIVE NASOPHARYNGEAL CARCINOMA——A CLINIC-PATHOLOGICAL STUDY OF 31 CASES

作者报道一种病程短,很快发生远处转移并导致死亡的鼻咽癌,称为迅速发展型鼻咽癌。其临床病理特点是:(l)患者从自觉症状至死亡的时间平均仅11.7个月。(2)多数患者来诊时已有大块或累及锁骨上区的颈淋巴结转移(N_3病例占51.6％)。(3)角化性鳞癌和非角化性癌所占比例较高(43.3％)。(4)癌组织中淋巴细胞,树状突细胞以及单核/巨噬细胞的浸润较少。临床大夫如能及时识别这一特殊类型的鼻咽癌,并采取相应措施,将达到减少远处转移,提高疗效的目的。

This paper reports 31 patients of a special type of nasopharyngeal carcinoma (NPC), named rapidly progressive NPC, the course of disease was very short and distant metastasis developed early, and then followed by death immediately. The clinic-pathological characteristics were: (1) The duration of the disease from its initial symptoms to death was only 11.7 months averagely: (2) Most patients had massive lymph-node metastsis or metastasis involving to supraclavical lymph node(s) (51.6% of the patients coded N 3); (3) The frequency of keratinizing squamous cell carcinoma and non-keratinizing carcinoma was higher. (4) The infiltrating of lymphocytes, dendritic cells and monocytes/macrophages within tumor tissue was always showing depletion. This results illustrated that if the clinicians could diagnose this special NPC type and apply appropriate means, the distant metastasis might be less developed and the treatment effect enhanced.