先天性遗传性白内障动物模型建立的实验研究

The creation and study of an inherited congenital cataract model in rats

用致畸剂(5-bromodeoxyuridine BRDU)成功地诱发大鼠先天性遗传性白内障动物模型:雌鼠动情期受孕率最高(81%),动情前期和间期受孕率均很小。不同剂量 BRDU 诱发仔一代先天性白内障形成概率及严重程度不同;仔二代遗传性白内障患病率也与 BRDU 剂量呈正相关。此白内障动物模型的建立将有助于探讨先天性白内障的病因和防治。

We used the teratogen 5-hromodeoxy- uridine(BRDU)in the creation of a model of inherited congenital cataract in Wistar rats.The highest rate of impregnation(81%) of the rats was observed during the period oestrus.The frequency of occurrence and the density of the congenital cataract in the F1 generation varied with the dosage of BRDU,and the frequency of the cataract in the F2 generation was positively correla- ted with the dosage of the drug.The crea- tion of this inherited congenital cataract model may be useful in exploring the etio- logy of the cataract and its prevention and treatment.