帕金森病和多系统萎缩患者脑脊液阿片肽含量变化的研究

A Study of Opioid Peptides Levels in CSF of Patients with Parkinson's Disease and Multiple System Degeneration

采用放射免疫法检测８例帕金森病（ＰＤ）和１３例具帕金森综合征的多系统萎缩（ＭＳＤ）患者脑脊液（ＣＳＦ）中β－内啡肽（β－ＥＰ）、亮脑啡肽（ＬＥＫ）、强啡肽Ａ_（１－１３）（ＤｙｎＡ_（１－１３））含量。发现患者组ＣＳＦ中β－ＥＰ和ＬＥＫ含量显著高于对照组，ＤｙｎＡ_（１－１３）含量变化不显著。帕金森病和多系统萎缩两组间ＣＳＦ中三种阿片肽含量相差不明显。提示且ＥＰ、ＬＥＫ含量增高可能与ＰＤ和ＭＳＤ患者所共有的肌张力增高和肌强直等锥体外系症状产生有关。

The levels of bata-endorphine(β-EP),leucine enkephalin (LEK)and dynorphin A(1-13)(DynA(1-13))in cerebraspinal fluid (CSF) were detected by radioimmunoassy in patients with Parkinsos's disease (PD,8 cases) and multiple system degeneration (MSD,13 cases).The results showed that the levels of β-EP and LEK significantly increased,but DynA(1-13) level was not obviously changed in CSF of the patients as compared with controls.The three kinds peptides levels between PD and MSD were not significantly different.It is indicated that the increase of β-EP and LEK might have correlation with the extrapyramidal symptoms.such as muscle hypertonicity and rigidity, shared with PD and MSD.