老年痴呆与血浆氨基酸水平的关系

Relationship between the Senile Dementia and the Level of Plasma Amino Acids

老年痴呆与血浆氨基酸水平的关系秦斌，彭丹涛，王爱军，王莹（北京医院神经内科，北京１００７３０）氨基酸作为神经递质，与老年痴呆发生的关系极为密切。８０年代初Ｇｒｏｗｄｏｎ和Ｃｏｒｋｉｎ［１］对老年痴呆患者脑脊液内氨基酸含量变化进行了测定，以后Ｓｍｉｔｈ...

Abstract The quantitative analysis of the 27 free anino acids in the plasma in Alzheimer′s disease (AD)group(17 cases),multi-infarct dementia (MID)group(33 cases)and control group was done.The results revealed that 17 amino acids(63.0%)in AD group and 8 amino acids (30.0%)in MID group were statistically significantly different from control group,and sug gested that there was a remarkable dysfunction of the metabolism of plasma amino acids in AD group.The mean concentration of 13(76.5%)from 17 plasma amino acids in AD group was significantly lower(including 5 essential amino acids and 3 side chain amino acids). The decreased mean concentration of some amino acids may indirectly reflect the disturbance of metabolism of amino acid in AD.The correlation of amino acid level between the plasma and brain in AD group need to be further studied.