巨噬细胞和粒细胞集落刺激因子在细菌性脑膜炎患者脑脊液中呈增高趋势

The Increasing Tendancy of Macrophage-colony Stimulating Factor(M-CSF)and Granulocyte-colony Stimulating Factor(G-CSF)in Cerebrospinal Fluid (CSF) of Patients with Bacterial Meningitis

检测了２４例细菌性脑膜炎（ＢＭ），２０例多发性硬化症（ＭＳ）和２０例肌紧张性头痛（ＴＨ）患者的脑脊液（ＣＳＦ）巨噬细胞集落刺激因子（Ｍ－ＣＳＦ）及粒细胞集落刺激因子（Ｇ－ＣＳＦ）。２４例ＢＭ患者中１９例检出Ｍ－ＣＳＦ，含量为６０～５６０Ｕ／ｍｌ；１６例检出Ｇ－ＣＳＦ，含量为４０～１２０Ｕ／ｍｌ。２０例ＭＳ组和２０例ＴＨ组均未检出。ＢＭ患者ＣＳＦ中Ｍ－ＣＳＦ和Ｇ－ＣＳＦ呈增高趋势。鉴于这两种细胞集落刺激因子可促使活性单核细胞、纤维细胞和内皮细胞产生某些细胞因子，从而增强机体抵抗细菌感染的能力，提示Ｍ－ＣＳＦ和Ｇ－ＣＳＦ在中枢神经系统感染性疾病中可能起到重要的免疫调节作用。

The levels of macrophage-colony stimulating factor(M-CSF)and granulocyte-colonystimulating factor(G-CSF)were detected in cererbrospinal fluid(CSF)of 24 patients with bacterial meningitis(BM),20 patients with multiple sclerosis(MS)and 20 subjects of tension headacheas normal control,It was found that M-CSF and G-CSF were detected only in BM patients,but not in MS and normal controls.M-CSF with level of 60-560U/ml was determined in 19 out of 24 BM patients and G-CSF with level of 40-120U/ml was detected in 16 out of 24 BM patients. This findings suggest that the increasing tendancy of M-CSF and GCSF in CSF of BM patients. It is supported that M-CSF and G-CSF drived from monocytes,fibroblasts and endothelial cells could produce some cytokines and enhance the ability against bacterial inflammation.It also demostrated that MCSF and G-CSF may play an important immunoregulatory role in infectious diseases of the central nervous system.