以药效法测定四物汤药动学参数的研究

Study on Determining Pharmacokinetics Parameters Siwu-Tongby Pharmacological Methods

以血小板聚集抑制率作为药理效应指标，研究了四物汤的药物动力学参数，同时以探索中药及复方的药动学研究方法为目的，对药理效应法研究药动学进行了比较研究。结果：家兔口服四物汤后符合开放一房室模型，药效吸收、消除半衰期是０．３７ｈ、０．４０ｈ，ｔｐ＝０．５６ｈ，效应维持时间１．９ｈ。建议应同时考察效量、药效、表观三种半衰期，在研究设计时应重视体现药动学和药效的双重性。

he pharmacokinetics parameters of Siwu-Tong was studied by the pharmecological methods. that is the bloodpletelet aggregation inhibition rate in order to explore methods of phernacokinetics about traditional chinese herbs andtraditional chinese prescriptions.Results showed that it was one-compartment model with first order absorption and lag time when Stwu-Tong was taken orally in the rabbits. t1 /2(ka) =0. 37h. t1 /2(ke) =0. 40h. tp=0. 56h. time of remaining effect was 1.9h. It is suggested that effect dose half-time. drug effect half-time. apparent half-time must be studied. On the other hand. we should attach greal importance to double character of pharmacokinetics and pharmacodynamics in the design of reseerch.