四君子汤治疗脾气虚型胃肠病SOD、MDA变化的研究

Study on SOD and MDA Changes in Patients with Spleen-QiDeficiency type Stomach-intestine Disease Treated with SiJunZi Decoction (四君子汤 )

用四君子汤治疗６０例脾气虚型胃肠病患者，观察治疗前后血清总超氧化物歧化酶（ＳＯＤ）、丙二醛（ＭＤＡ）值，并与正常对照组比较。脾虚患者ＳＯＤ低于对照组（Ｐ＜０．０１），而ＭＤＡ偏高（Ｐ＜０．０１），治疗后与对照组无显著差异（Ｐ＞０．０５）。提示：脾虚患者自由基清除能力下降，脂质过氧化反应增强，四君子汤能逆转此病理过程。

n the study, we used SiJunZi Decoction to treat 60 patients with Spleen-Qi Deficiency (SQD) type stomach-intes-tine disease. we observed the total SOD and MDA level in serum before and after treatment. and compared them withnormal control group. The results showed that the SOD of SOD type cases before treatment was very lower than control group(P>O. 01 ) and the MDA was very higher (P<0. 01 ). The difference in the level of SOD and MDA betweenbefore and after treatment was very significant (P<0. 01 ). This study showed that in patients with SOD type stomachintestine disease. the power of cleaning free radical and LPO was low. SiJunZi Decoction can clean free radical andLPO of the body. It is one of the mechanisms of SiJunZi Decoction to invigorate Spleen-Qi.