人参茎叶皂甙调节创伤小鼠白介素2及白介素2受体基因表达的实验研究

Experimental Study on Regulatory Effect of Ginsenoside of Stem and Leafon Interleukin 2 and Interleukin 2 Receptor Gene Expression in Traumatized Mice

小鼠皮下注射人参茎叶皂甙（ＧＳＬ）５０ｍｇ／ｋｇ，连续４天，可明显对抗创伤小鼠淋巴细胞白介素２（ＩＬ－２）ｍＲＮＡ、ＩＬ－２受体（ＩＬ－２Ｒ）ｍＲＮＡ、ＩＬ－２、ＩＬ－２Ｒ水平的受抑状态，并降低创伤小鼠血清、巨噬细胞、ＴＳ细胞对正常淋巴细胞ＩＬ－２ｍＲＮＡ、ＩＬ－２ＲｍＲＮＡ的抑制作用。０．１～１００ ｇ／ｍｌ的ＧＳＬ在体外可升高创伤小鼠淋巴细胞ＩＬ－２ｍＲＮＡ及Ｌ－２ＲｍＲＮＡ水平，表明ＧＳＬ可增强创伤后ＩＬ－２Ｒ及ＩＬ－２Ｒ的基因转录表达。

ubcutaneous administration of ginsenoside of stem and leaf (GSL) at dosage of 50mg/kg 4d, could resist the suppression of lymphocyte interleukin 2 (IL-2) mRNA, IL-2 receptor (IL-2R) mRNA, IL-2, IL-2R levels significantlyintraumatized mice, also reduce the suppressive effects of serum, macrophages, Ts cells from traumatized mice on lymphocyte IL--2 mRNA and IL-2R mRNA of normal. GSL ranging from 0. 1 to 100 g/ml could elevate lymphocyte IL2 mRNA and IL-2R mRNA levels in traumatized mice. It is suggested that GSL can enhance IL-2 and IL-2R genetranscription expression after trauma.