摘要
山姜水煎剂对幽门结扎型、应激型及利血平型大鼠实验性胃溃疡均有不同程度的抑制作用，但对消炎痛型胃溃疡作用不明显。它能增加胃液及胃蛋白酶活性，降低总胃酸与游离盐酸。对离体胃条有短暂收缩兴奋，随即转入抑制，降低胃张力和拮抗乙酰胆碱引起的胃收缩。
he decoction of Alpinia japonica (DAJ) at dose tanged from 5 to 20g/kg was found to have anti--ulcer effect inthree experimental gastric ulcer models in rats induced by pyloric ligation, stress-restraint and reserpine, respectively.However. DAJ was shown to be ineffective against the indomethacin-induced ulcer model. In the pyloric ligation ulcermodel DAJ was found to be able to inhibit the increased gastric total acidity and free acidity, but the volume of gastricjuice and activity of pepsin were increased. In addition, in the rat fundus strip in vitro experiments, DAJ producedtransient excitant effect in initial and then inhibitory effect, reducing gastric tension. It could also markedly antagonizethe spasmodic constriction induced by acetylcholine.
出处
《中药药理与临床》
CAS
CSCD
1995年第4期29-31,共3页
Pharmacology and Clinics of Chinese Materia Medica
