石膏注射液中枢镇痛作用的实验研究

Central Analgesia of Gypsum injection:an Experimental Study

实验用三碘季铵酚制动猫进行，以隐神经Ｃ类纤维传入冲动引起的大脑皮层体感区诱发电位（Ｃ－ＣＥＰ）为慢痛指标。结果表明，在３４例实验中，静脉注射石膏注射液使２６例（７６．４７％）的Ｃ－ＣＥＰ峰一峰值明显衰减甚至消失，６例（１７．６５％）的Ｃ－ＣＥＰ峰一峰值无明显变化，２例（５．８８％）的Ｃ－ＣＥＰ峰－峰值增大。石膏注射液对Ａ类纤维传入引起的体感皮层诱发电位（Ａ－ＣＥＰ）无明显影响。石膏注射液对Ｃ－ＣＥＰ的抑制作用既能被纳洛酮翻转，又能放异搏定所拮抗。提示石膏注射液具有较明显的选择性中枢镇痛作用，其中枢镇痛作用可能与Ｃａ２＋及内阿片肽释放有关。

n this study,the somatosensory conical evoked potential elicited by C-fiber inputs of the saphenous nerve (CCEP) was used as an index of chronic pain in flaxedil -paralyzed oats.The results showed that among 34 subjects received Gypsum injection intravenously, C-CEP was significantly surpressed in,26 (76.47%), unchanged in 6(17.65% ) and enhanced in 2 (5.88% ). Gypsum injection had no effect on the somatasensory conical evoked potential elicited by A-fiber inputs of the saphenous nerve (A-CEP). The inhibitory effects of Gypsum injection on C-CEPcan be-blocked by both naloxone and verapamil.It is suggested that Gypsum injection Possesses a selective central analgesia,in which Ca2+ and endogenous opiate Peptides might play an important role.