摘要
实验用三碘季铵酚制动猫进行,以隐神经C类纤维传入冲动引起的大脑皮层体感区诱发电位(C-CEP)为慢痛指标。结果表明,在34例实验中,静脉注射石膏注射液使26例(76.47%)的C-CEP峰一峰值明显衰减甚至消失,6例(17.65%)的C-CEP峰一峰值无明显变化,2例(5.88%)的C-CEP峰-峰值增大。石膏注射液对A类纤维传入引起的体感皮层诱发电位(A-CEP)无明显影响。石膏注射液对C-CEP的抑制作用既能被纳洛酮翻转,又能放异搏定所拮抗。提示石膏注射液具有较明显的选择性中枢镇痛作用,其中枢镇痛作用可能与Ca2+及内阿片肽释放有关。
n this study,the somatosensory conical evoked potential elicited by C-fiber inputs of the saphenous nerve (CCEP) was used as an index of chronic pain in flaxedil -paralyzed oats.The results showed that among 34 subjects received Gypsum injection intravenously, C-CEP was significantly surpressed in,26 (76.47%), unchanged in 6(17.65% ) and enhanced in 2 (5.88% ). Gypsum injection had no effect on the somatasensory conical evoked potential elicited by A-fiber inputs of the saphenous nerve (A-CEP). The inhibitory effects of Gypsum injection on C-CEPcan be-blocked by both naloxone and verapamil.It is suggested that Gypsum injection Possesses a selective central analgesia,in which Ca2+ and endogenous opiate Peptides might play an important role.
出处
《中药药理与临床》
CAS
CSCD
1995年第5期22-26,共5页
Pharmacology and Clinics of Chinese Materia Medica
关键词
石膏注射液
镇痛作用
实验
药理学
C类纤维
C-fiber
conical evoked Potential
pain
Gypsum
naloxone
verapamil