番泻甙对大鼠心肌收缩性能的影响

Effects of sennosides on myocardial COniractility in rats

麻醉大鼠实验结果表明，番泻甙（７．４ｕｍｏｌ·Ｌ－１·Ｋｇ－１）ｉｖ具有正性肌力作用。给药后ＨＲ加快，ＳＰ、ＭＡＰ和ＬＶＰＳ较对照组明显升高（Ｐ＜０．０５）。ｔ－ｄｐ／ｄｔｍａｘ缩短，与ｄｐ／ｄｔｍａｘ、ＶｃＥ－ＣＰＩＰ和Ｖｍａｘ增加相一致。反映心肌消耗能量与耗氧的ＴＴＩ．ＨＲ在给药后５ｍｉｎ时较对照组增加５６％，１０ｍｉ。时增加８０％，说明番泻甙升压增加左室作功，从而使心肌耗氧耗能增加。

he results were shown in anesthetized rats SEN (sennosides) possesses a positive inotropic effects. after vein administration.The HR was increased,theSP,MAP and LVPS were obviousty elevated compared With that of the control groups (P<0.01 ). The shortening of t-dp/dtmax was consistent with the increases dp/dtmax, Vce-CPIP and Vmax TheTTI. HR (minute tension time index), as a standard for both.myocardial energy and oxysen consumption, was increase of 56% and 80% respectively after administration of SEN in 5min and 10min compared with control groups.This paper showed the SEN increase left ventricle working load,and consequently increase the myocardial consumptionof energy.