慢性肾衰患者血液透析前后血浆心钠素和环核苷酸水平的变化

PLASMA LEVELS OF CYCLIC NUCLEOTIDE AND ANF BEFORE AND AFTER HEMODIALYSIS IN CRF PATIENTS

心钠素和环核苷酸水平的变化对于肾脏的基础和临床研究具有十分重要的意义。为了进一步观察心钠素和环核苷酸水平在肾功能不全发病中的作用,本文对34例CRF病人血液透析前后血浆ANF、cAMP、cGMP水平进行分析。结果显示,CRF患者透析前血浆ANF、cAMP、cGMP含量均显著高于健康人(p<0.001),cAMP/cGMP比值则显著低于健康人(p<0.01)。而经过血透后ANF、cAMP,cGMP含量又明显下降(p<0.001),提示CRF的发病机理与ANF、cAMP、cGMP水平的改变有密切的关系。同时初步分析了这些变化的原因及意义。因此,我们认为测量血浆ANF、cAMP、cGMP水平的变化,对CRF患者的诊治有一定的指导意义。

Changes of cyclic nucleoside phosphate and artial natriuretic factor(ANF) are of great importance to basic and clinic research in kidney diseases. We studied the changes of the plasma levels of cyclic adenosine monophosphate (cAMP), cyclic guaaosine monophosphate (cGMP) and ANF before and after hemodialysis in 34 cases of chronic renal failure (CRF) patients. The results showed that cAMP, cGMP and ANF levels in the CRF patients were markedly higher than those of the normal control (P<0.001), but cAMP/cGMP ratio was significantly ower (p<0.01). After hemodialysis the values were lowered significantty(p<0.001), suggesting that close relationship existed between their plasma revels and pathogenesis of CRF. Determination of these levels was of importance in the diagnosis and treatment of CRF.