食道贲门癌患者手术期胃动素与胃泌素的动态观察

DYNAMIC OBSERVATION OF GASTRIN AND MOTILIN LEVELS IN PATIENTS WITH ESOPHAGOCARDIAC CANCER DURING PERI-OPERATION PERIOD

本文采用放射免疫分析法对58例食道贲门癌患者围手术期进行了血浆胃动素与血清胃泌素的检测。结果显示,58例食道贲门癌患者在手术后第三天血清中胃泌素浓度明显增高,较正常对照组和术前对照组均有显著性差异(p<0.05)术后2周逐渐下降至正常。胃动素较正常对照组增高显著。在术后1天呈下降趋势,与对照组比较有显著性差异(p<0.01)。术后3天迅速上升,较对照组与自身对照组均增高显著(p<0.01)。术后1周开始下降,至3月恢复术前水平。胃泌素与胃动素在癌症手术期间的变化与手术刺激引起神经系统的改变和神经体液的调节有关。

In this report, we determined the gastrin, and motilin levels in patients with esophagocardiac cancer during peri-operative period with RTA. The results showed that the average gastrin concentration of the 58 operated patients increased significantly three days after operation as compared with that, in normal controls and preoperatively (p<0.05). It returned to normal two weekly later. Mean value of motilin concantration was higher in cancer patients than that in controls. One day after operation, it showed atendency to fall, significantly (P <0.01). Three days after operation, motilin level again increased rapidly and significantly (P<0.01). One week afteroperation, it began to decrease, and restored to normal in three months time. The variation of gastrin and motilin levels during peri-operative period was correlated to nervous system activity caused by operative stimulation through neurohumoral pathways.