急性白血病细胞DNA指数、DNA倍体变化的临床意义

Clinical effect of the changes of DNA index and DNA ploidy of leukemia cells in the peripheral blood of acute leukemia

目的观察不同病期急性白血病患者外周血白血病细胞DNA指数及DNA倍体的变化,探讨其与预后的关系,指导临床诊断和治疗。方法应用流式细胞术(FCM)检测58例急性白血病患者DNA指数和DNA倍体。结果急性白血病完全缓解(CR)者DNA指数、DNA非整倍体率均明显低于复发者,初治CR者明显低于初治非CR者。结论初诊时表现为DNA整倍体及低DNA指数的急性白血病患者具有较好的治疗效果。DNA指数和DNA非整倍体率可作为制定急性白血病患者化疗方案时的重要参考指标。

Objective To observe the DNA index and DNA ploidy of leukemia cells in the peripheral blood of acute leukemia patients and to find their relationship with clinical features so as to guide clinical diagnosis and treatment.Methods The DNA index and DNA ploidy of acute leukemia cells were studied by flow cytometric analysis(FCM).Results DNA index and DNA aneuploidy in complete remission (CR) leukemia patients were lower than those in radical relapsed groups(P<0.05).DNA index and DNA aneuploidy in patients achieving CR were lower than those of patients failing to achieve CR treated immediately after diagnosis(P<0.05).Conclusion The treatment of acute leukemia patients with diploids and lower DNA index is more effective.DNA index and aneuploidy may be regards as an important reference in prescribing chemotherapy regiments for acute leukemia.