胃溃疡与胃癌患者Hp感染与血清学检测

The relation between serologic test and Hp infection in patients with gastric ul cer and gastric cancer

目的:研究血清学检测在诊断胃溃疡与胃癌患者幽门螺杆菌(Helicobacterpylori,Hp)感染中的意义。方法:对144例胃溃疡患者与86例胃癌患者行抗Hp-IgG抗体血清学检测与快速尿素酶试验,比较检测结果。结果:胃溃疡患者快速尿素酶试验及血清抗Hp-IgG抗体检测阳性率分别为74.3%和88.2%,而胃癌患者分别为41.9%和72.1%。结论:胃癌和胃溃疡患者血清抗Hp-IgG抗体阳性率明显高于快速尿素酶试验,在胃溃疡及胃癌患者中单独应用快速尿素酶试验有可能影响Hp的检出率。

Objective To investigate the role of serology in Helicobacter pylori(H.pylori)diagnostic in patients with gastric cancer and gastric ulcer.Method144gastric ulcer and86gastric cancer patients were enrolled in this study.Serum samples from both groups were tested for specific IgG antibodies were enrolled in this study.Serum samples from both groups were tested for specific IgG antibodies to H.pylori,using enzyme-linked immunosorbent assay(ELISA).Gastric biopsy specimens obtained during endoscopy were also used for rapid urease test(RUT).Results H.pylori was detected in107(74.3%)gastric ulcer patients by RUT and in127(88.2%)by serology.In-creased serum antibodies levels indicating H.pylori infection were found in62(72.1%)gastric cancer patients,whereas RUT was positive in only36(41.9%).The difference between serology and RUT was highly significant (P<0.005).Conclusion Positive tates of serology in patients with gastric ulcer and gastric cancer were significantly higher than RUT.The prevalence of H.pylori infection might be underesti-mated in patients with gastric ulcer and gastric cancer if only biopsy based diagnostic methods were used.