非硝苯地平钙离子拮抗剂与牙龈增生的关系研究

THE RELATIONSHIP BETWEEN NON-NIFEDIPINE CALCIUM ANTAGONISTS AND GINGIVAL HYPERPLASIA

目的 :探讨服用非硝苯地平的钙离子拮抗剂 (除硝苯地平之外的其他钙离子拮抗剂 )与牙龈增生的关系。方法 :选择北京医院内科高血压门诊就诊的成年高血压病患者 ,进行问卷调查和口腔健康检查。分为服用非硝苯地平钙离子拮抗剂的患者 (简称服药组 )及从未服用过钙离子拮抗剂的患者 (简称对照组 )。问卷调查内容包括患者的一般状况 ,高血压患病史 ,服药史以及口腔卫生习惯等。口腔健康检查包括菌斑指数 (plaqueindexPLI)、简化牙石指数 (simplecalculusindexCI S)、以及牙龈增生指数 (gingivalhyperplasiaindexHI)的检查和记录。 结果 :对照组患者牙龈增生患病率 6 0 3% ,服药组患者牙龈增生患病率 31 2 5 % ,两者间的差异有显著性 (P <0 0 0 1) ,并且服药组患者中严重牙龈增生的患病率 19 2 3%也显著高于对照组 1 5 9% (P <0 0 0 1)。对照组平均HI值为 1 4 % ,服药组平均HI值为 10 % ,两者间的差异有显著性 (P <0 0 0 1)。结论 :服用非硝苯地平钙离子拮抗剂与高血压患者牙龈增生的患病间有显著相关性。

Objective: To investigate the relationship between using non-nifedipine calcium antagonists and the prevalence of gingival hyperplasia among Chinese adults with hypertension. Methods: The Chinese adult patients with diagnosed hypertension,were included in the study and divided into two groups:calcium antagonist group that had been taking non-nifeidipine for over 3 months,control group that had never taken any calcium autagouist.Oral health examination was performed by a qualified dentist in the Dental Department of Beijing Hospital.The plaque index(PLI),the simplified calculus index(CI-S),and the gingival hyperplasia index(HI)were recorded.Each patient completed a structured questionnaire,on which the information on medical history,health status and mediation on nypertension were obtained.Gingival hyperplasia was found in 31 .25% of patients who took calciun antagonist and 6 .03% of patieuts in the control group( P <0 .001).Furthermore,the proportion of patients with severe gingival hyperplasia(HI>30%)was significantly higher in the antagonist group than in the coutral group. Conclusion: This study suggests that there is significant co-relationship between using non-nifedipine calcium antagonists and the prevalence of gingival hyperplasia.