改良PUVA疗法治疗慢性斑块性银屑病疗效分析

Treatment of chronic plaque-type psoriasis with modified PUVA therapy

目的 : 探索用改良PUVA疗法治疗慢性斑块性银屑病的疗效和安全性。方法 : 6 7例寻常型银屑病患者口服 8-MOP 0 .6mg kg后照射UVA和UVB ,每周 3次 ,共治疗 8周 ,用PASI积分评价疗效 ,并记录不良反应。结果 : 治疗开始 2～ 4周后出现疗效 ,随着治疗时间的延长 ,PASI总积分逐渐下降 ,有效率逐渐提高 ,在治疗结束时痊愈率达到 96 .5 % ,有效率达 10 0 %。 2 7例患者 (40 .3% )出现不良反应 ,绝大多数为轻度 ,没有因不良反应停止治疗的病例。结论 : 改良PUVA疗法治疗慢性斑块性银屑病具有良好疗效和安全性。

Objective: To assess the efficacy and safety of modified PUVA therapy in the treatment of chronic plaque-type psoriasis. Methods: Sixty-seven patients were treated with a modified PUVA regimen, 3 times a week for 8 weeks. On each treatment, the patients took 8-methoxypsoralene (8-MOP) at dose of 0.6mg/kg, and then, UVA and UVB radiation were followed 2 hours after the oral medication. The efficacy was assessed by change in PASI score and the adverse events were recorded. Results: The efficacy appeared after the treatment in 2 to 4 weeks and the lesions were improved with time. At the end point, all patients showed marked improvement with a cure rate of 96.5%. Twenty-seven patients (40.3%) experienced systemic or local adverse reactions, most of which were mild. Conclusion: The current study demonstrates that the modified PUVA therapy is effective and safe in the treatment of chronic plaque-type psoriasis.