早期梅毒患者脑血流灌注显像研究

Cerebral blood flow perfusion imaging by single photon emission computed tomography in patients with early syphilis

目的 了解早期梅毒患者的脑血流灌注情况。方法 病例组为 32例早期梅毒患者 ,对照组为 15名健康人 ,对两组对象行99mTc 双半胱乙酯脑血流灌注显像 ,并作图像视觉分析。结果 病例组 32例均有弥漫性、斑片样脑血流低灌注 ,14例患者在多个局部表现得更为明显 ,共 4 6例次。其中累及左额叶 6例次 ,右额叶 3例次 ,左顶叶 7例次 ,右顶叶 6例次 ,左颞叶 11例次 ,右颞叶 5例次 ,左枕叶 3例次 ,左基底节 3例次 ,小脑和脑内核团各 1例次。对照组无一人异常。结论 早期梅毒患者均已存在脑血流异常 ,单光子发射计算机断层图像普遍显示弥漫性。

Objective To study the cerebral blood flow perfusion imaging by single photon emission computed tomography (SPECT) in patients with early syphilis. Methods SPECT was performed with 99m Tc ECD as imaging agent on 32 patients with early syphilis and 15 healthy controls. Visual analysis was made. Results Disseminated patchy radioactive rarefection mainly in cerebral cortex, suggesting hypoperfusion of regional cerebral blood flow, was shown in all patients. In particular 14 patients displayed multi regional obvious hypoperfusion patches: 6 in left frontal lobe, 3 in right frontal lobe, 7 in left parietasl lobe, 6 in right parietal lobe, 11 in left temporal lobe, 5 in right temporal lobe, 3 in left occipital lobe, 3 in left basal ganglia, 1 in cerebellum, and 1 in intrecerebral nucleus. No abnormality was found in the controls. Conclusion Cerebral blood flow abnormality exists in patient with early syphilis manifesting as patchy hypoperfusion in SPECT imaging.