摘要
阿片肽及阿片受体分布于心肌组织 ,通过G蛋白耦联和细胞内信号转导参与心肌缺血预适应 (IPC) ,既具有即刻保护作用 (第一时间窗 ) ,又具有延迟保护效应 (第二时间窗 )。目前采用的“触发剂 调节介质 终末效应器”分子理论机制 。
Through G protein coupling and intracellular signal transmission, opioid peptides and its receptors in myocardial tissues participate in IPC have the function of early and delayed protection. The molecular mechanism of ”trigger-regulatory medium-effector” is of great significance in the study of the pathogenesis of IPC, as well as exploring the new idea for CHD prevention and cure.
出处
《医学研究生学报》
CAS
2004年第12期1135-1137,1150,共4页
Journal of Medical Postgraduates
关键词
阿片肽
阿片受体
信号转导
缺血预适应
Opioid peptides
Opioid receptors
Signal transmission
IPC