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阿片肽参与心肌缺血预适应的分子机制 被引量：9

Molecular mechanisms of opioid peptides in myocardial ischemic preconditioning
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摘要 阿片肽及阿片受体分布于心肌组织 ,通过G蛋白耦联和细胞内信号转导参与心肌缺血预适应 (IPC) ,既具有即刻保护作用 (第一时间窗 ) ,又具有延迟保护效应 (第二时间窗 )。目前采用的“触发剂 调节介质 终末效应器”分子理论机制 。 Through G protein coupling and intracellular signal transmission, opioid peptides and its receptors in myocardial tissues participate in IPC have the function of early and delayed protection. The molecular mechanism of ”trigger-regulatory medium-effector” is of great significance in the study of the pathogenesis of IPC, as well as exploring the new idea for CHD prevention and cure.
作者 肖继明 陈锐华
机构地区 南京军区南京总医院南京大学医学院临床学院心血管内科
出处 《医学研究生学报》 CAS 2004年第12期1135-1137,1150,共4页 Journal of Medical Postgraduates
关键词 阿片肽 阿片受体 信号转导 缺血预适应 Opioid peptides Opioid receptors Signal transmission IPC
分类号 R542.2 [医药卫生—心血管疾病]
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参考文献22

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二级参考文献22

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医学研究生学报
2004年 第12期

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