尿中修饰核苷在胃癌诊断中的意义

Significance of Urinary Modified Nucleosides in Diagnosis for Gastric Cancer

[目的]探讨尿中修饰核苷检测在胃癌诊断中的价值。[方法]应用高效液相色谱方法分别检测80名正常人与60例胃癌患者尿中Pseu、C、X、m1A、m2G和ac4C等6种核苷的水平。[结果]60例胃癌患者尿中6种核苷的平均水平明显高于正常人(P<0.01);C与肿瘤大小呈正相关(P<0.05);Pseu、X、m1A、m2G和ac4C与肿瘤TNM分期呈正相关(P<0.05)。[结论]尿中修饰核苷检测对胃癌的诊断有一定意义。

To investigate the value of detection of urinary modified nucleosides in diagnosis for gastric carcinoma. Six kinds urinary nucleosides(Pseu, C, X, m1A, m2G and ac4C) from 80 healthy persons and 60 cases with gastric carcinoma were examined by high-performance liquid chromatography combined pattern recognition system. The average levels of 6 kinds nucleosides from patients with gastric carcinoma were higher than those from health persons (P<0.01). The level of nucleoside C was positively correlated to the tumor size(P<0.05). The level of nucleoside Pseu, C, X, m1A, m2G and ac4C were positively correlated to TNM staging(P<0.05). [Conclusion] Urinary modified nucleoside may be helpful in the diagnosis for gastric carcinoma.