拉米夫定治疗后慢性乙型肝炎患者的生活质量测评

The assessment of life quality of patients with chronic hepatitis B after the treatment with lamivudine

目的 评价拉米夫定对慢性乙型肝炎患者生活质量的影响 ,探讨临床防治重点。方法 应用健康状况调查问卷 ,对中南大学湘雅第二医院传染科 2 0 0 2 - 0 7～ 2 0 0 3- 0 7的 15 0例慢性乙型肝炎患者及 5 0名健康者生活质量研究 ,并对拉米夫定治疗前后的临床客观指标和生活质量主观指标进行对照分析 ,综合评价拉米夫定的疗效。结果 慢性乙型肝炎患者生活质量评分与对照组相比差异有显著意义 (P <0 0 1) ;拉米夫定治疗前后临床症状、血液学和病原学检查等客观指标及生活质量评分均差异有显著意义 (P <0 0 1)。结论 慢性乙型肝炎患者的生活质量普遍下降 ,拉米夫定能改善临床客观指标和提高患者的生活质量 ;在慢性乙型肝炎的防治中 ,生活质量可以作为效果评价指标 ,指导临床治疗方法的选择和决策。

Objective To assess the life quality of patients with chronic hepatitis B after the treatment of lamivudine,to find an ideal way of medical treatment for the chronic hepatitis B.Methods The quality of life of 150 patients with chronic hepatitis B and 50 healthy controls were assessed by the quality of life questionnaire.The laboratory data and marks of questionnaires were compared before and after the using of lamivudine in order to assess its comprehensive curative effect on chronic hepatitis B.Results The marks of SF-36 of chronic hepatitis were significantly different compared with those of control group (P<0.01).There were significant differences between the marks of quality of life before and after the treatment of lamivudine.Conclusion The quality of patients with life of chronic hepatitis B is universally reduced,and can be improved by the use of lamivudine.Assessment of quality of life may be taken as an important index in the prevention and treatment of chronic hepatitis B.