国产头孢呋辛治疗细菌性下呼吸道感染临床评价

Clinical Evaluation of Domestic Cefuroxime in the Treatment of Bacterial Lower Respiratory Tract Infec-tions

目的 :评价国产头孢呋辛治疗细菌性下呼吸道感染的有效性和安全性。方法 :采用随机对照开放试验方法 ,以进口头孢呋辛钠为对照药、国产头孢呋辛钠为试验药分别治疗受试者 ,疗程均为7d～14d。结果 :试验组与对照组有效率分别为90 00 %、87 50 % ,细菌清除率分别为90 91 %、94 12 % ,不良反应发生率分别为7 32 %、9 76 % ,两组临床有效率、细菌清除率和不良反应发生率均无显著性差异 (P<0 05)。结论 :国产头孢呋辛治疗细菌性下呼吸道感染安全、有效。

OBJECTIVE:To evaluate the efficacy and safety of domestic cefuroxime in the treatment of bacterial lower respiratory tract infections.METHODS:A randomized controlled clinical study of cefuroxime was conducted and the results were compared with these of zinacef.The duration of treatment was7～14days in both groups.RESULTS:The overall efficacy rates were90.00%for the cefuroxime group and87.50%for the zinacef group.The bacterial clearance rates were90.91%and94.12%,the adverse drug reaction rates were7.32%and9.76%respectively.There were no statistical differences between two groups in the overall efficacy rates,the bacterial clearance rates and the adverse drug reaction rates.CONCLUSION:Domestic cefuroxime appears to be a highly effective and safe agent for the treatment of bacterial lower respiratory tract infections.