135例患者应用葛根素注射剂安全性分析

Analysis of the Safety of Puerarin Injection Used in 135 Patients

目的 :了解葛根素注射剂在临床应用中的安全性。方法 :对2002年10月～2003年2月我院所有使用葛根素注射剂的住院患者用药情况及出现的不良反应进行调查。结果 :按照药品说明书规定的剂量 ,以0 9 %氯化钠注射液和5 %葡萄糖注射液作为溶媒 ,单独配制且单独输注 ,输注速度40～60滴/min时较为安全 ,不良反应少 ;超剂量用药 ,不良反应显著增加。结论 :应严格按照药品说明书的规定用药。

OBJECTIVE:To understand the safety of Puerarin injection in clinical use.METHODS:The adverse drug reˉactions(ADRs)and administration of Puerarin injection at Xuanwu Hospital from Oct.2002to Feb.2003were investigatˉed.RESULTS:According to the dosage in drug intruction,the Puerarin injection was diluted in0.9%sodium chloride of5%glucose solution and infused alone with a infusion rate of40～60drops/min,which would be safe and induce less ADRs,and use in overdose markedly increased the incidence of ADRs.CONCLUSION:Use of this preparation should strictly be in accordance with the specification.