对甲氧基苯甲酰-4-氨基丁酸HPLC标准物的制备

The preparation of standard material of P-methoxybenzoyl-4-aminobutanoic acid used for HPLC

目的 寻求标准品对甲氧基苯甲酰 4 氨基丁酸的最简制备方法。方法 以对羟基苯甲酸为原料 ,经三步合成 ,即原料的醚化、酰氯制备和酰胺化。用H1 NMR谱和MS鉴定所得产品的结构。结果 实验得到的样品经核磁共振波谱和质谱鉴定 ,证明是该化合物。结论 本文提供的制备方法简单可行 。

Objective Find the simple method to preparate P-methoxybenzoyl-4-aminobutanoic acid.Methods The substance was synthesized from P-hydroxybenzoic acid through three steps,those are etherification,preparation of acyl halide and amidation of the raw material.The product obtained was identified by H 1NMR spectrum and MS for its structure.Results H 1NMR spectrum and MS of the product obtained in the experiment shows that it is aim molecule.Conclusion The route described in this paper to prepare aim compound is simple and doable,the preparation craftwork in stabilization,creditable and can be used to prepare other compound of peptide.