氟骨症患者尿中骨吸收代谢产物含量分析

Analysis of contents of bone resorption products in urine of skeletal fluorosis patients

目的 观察饮水型氟骨症患者尿中骨吸收代谢产物的改变及其相互间的关系。方法 采用氯胺T法测定氟病区 67名氟骨症患者以及非病区 2 5名对照者的尿中羟脯氨酸含量 ,氟离子选择电极法测定尿氟 ,等离子体光谱仪测定尿中钙、磷、镁、锌含量 ,并均以尿肌酐进行校正。结果 各组之间尿钙、磷、镁、锌、HOP/Cr含量均无差异性 (P >0 .0 5 ) ,各组之间尿氟含量有差异性 (P <0 .0 1)。 4个组的尿F与尿Mg之间 ,尿Ca与尿Mg之间均有正相关关系 (P <0 .0 5 ) ;对照组、轻度组、中度组的尿F与尿Ca之间有正相关关系 (P <0 .0 5 )。中度组的尿HOP/Cr与尿Ca之间 ,尿HOP/Cr与尿P之间有正相关关系 (P <0 .0 5 )。结论 高氟所致的骨吸收代谢紊乱是不容忽视的 ,并且脱离高氟后不能完全恢复 ;氟骨症患者尿氟与骨矿物质代谢以及胶原降解有一定的关系。

Objective To investigate the changes of bone resorption products in urine of skeletal fluorosis patients and analyse their interactive relations. Methods Choose 67 cases of skeletal fluorosis patients from endemic fluorosis region in Xinjiang and 25 cases without skeletal fluorosis as control from no endemic fluorosis region. Hydroxyproline(HOP) and Cr in urine were determined by biochemical methods. Fluoride in urine was determined by electrode method. Ca, P, Mg and Zn were examined by ICP. Results The contents of Ca,P,Mg,Zn and Hop/cr in urine were no different (P>0.05)in four groups.The contents of fluoride in urine were significant difference (P<0.01)among each group.F and Mg,Ca and Mg in urine were positive correlativity (P<0.05)in four groups.F and Ca in urine were positive correlativity (P<0.05)in control and two skeletal fluorosis patients groups.Hop/cr and Ca,Hop/cr and P in urine were positive correlativity(P<0.05) in skeletal fluorosis patients group. Conclusions High level of fluoride in drinking water can influence bone resorption of human. There is relationship in the catabolism of bone mineral, bone collagen and bone fluoride.