苦参碱抗肝纤维化治疗的临床研究

Effects of matrine on anti hepatic fibrosis

目的 :研究苦参碱治疗慢性肝病的临床疗效、对肝纤维化的影响及抗肝纤维化的作用机理。方法 :苦参碱 (斯巴特康 )注射液 2 0 0mg加入 10 %葡萄糖注射液 2 5 0ml静脉滴注 ,1/d ,8周为一疗程。以甘利欣 ,丹参注射液作对照组。结果 :苦参碱组显效率与对照组比较有显著差异 (P <0 .0 1) ;在胆红素及转氨酸复常方面 ,苦参碱组亦优于对照组 ,有显著差异 (P <0 .0 5 )。两组治疗前后肝纤维化指标检测结果 ,治疗组与对照组治疗后比较有显著差异 (P <0 .0 5 )。结论 :该药使用安全 ,对HA ,LN ,PCⅢ ,Ⅳ -C的合成有抑制作用 。

Objective:To elucidate the mechanism of matrine on anti hepatic fibro sis. Methods: Randomly divided into 2 groups: matrine treatment group and control group. The matrine treatment group was give n matrine 200 mg per day by intravenous injection,and the control group was admi nistered Diammonium Glyeyrrhizinate 30 ml and Danshen 14 ml by intravenous injection.The therapeutic course was 8 week.Serum fibrosis markers were measure d by RIA. Results:At the end of treatment, the leve ls of serum ALT, AST, TBil and fibrosis markers were lower in matrine group than those in control group. Conclusion:The result indicated that matrine can ameliorate the inflammatory activity and fibrogenesis in chronic hepatitis.