PJ-CW对巨噬细胞功能的调变

Modulation of Macrophage Function by Pseudomonas Jinanensis Cell Wall

本文研究了济南假单胞菌细胞壁组分(PJ-CW)对巨噬细胞功能的调变作用,其结果显示:PJ-CW体外活化的小鼠腹腔巨噬细胞能够抑制肿瘤细胞P815的增殖。PJ-CW与巨噬细胞活化因子(MAF)共同作用,能显著增强巨噬细胞对肿瘤细胞的抑制作用。PJ-CW体外处理的巨噬细胞对ConA诱导的淋巴细胞增殖的抑制作用明显降低。

A new bacterial extract, Pseudomonas Jinanensis Cell Wall (PJ-CW), was used to investigate its modulation of macrophage function. The mouse peritoneal M φ activated by PJ-CW in vitro had the cytostatic activity to tumor cell(P815)>and macrophage activating, factor (MAP) significantly increased this effect . In addition .the suppression of normal syngeneic peritoneal Mφ on ConA-induced proliferation of mouse splenic lymphocytes could be markably reduced if peritoneal Mφwere pretreated in vitro with PJ-CW.