PJ-CW对巨噬细胞细胞毒功能的调节

Regulation of Macrophage-mediated Cytotoxic Activity by PJ-CW in vitro

本文以检测巨噬细胞介导的肿瘤细胞溶解作用为手段,研究了济南假单胞菌细胞壁组分(PJ-CW)体外对小鼠腹腔巨噬细胞细胞毒功能的调节作用。结果表明:PJ-CW本身能活化巯基乙醇酸钠培养液诱导的巨噬细胞,在10μg/ml时巨噬细胞介导的肿瘤细胞溶解作用达高峰。PJ-CW与巨噬细胞活化因子(MAF)共同作用,能显著增强巨噬细胞的细胞毒性。同时就PJ-CW对巨噬细胞功能的这种调节作用在肿瘤免疫中的重要性进行了简要讨论。

It was investigated about the regulatory function of Pseudomonas Jinanensis Cell Wall (PJ-CW)on mouse peritoneal macrophage-mediated cytotoxic activity in vitro. Macrophage-mediated tumor cell lysis (MTC) was assayed. The results showed that PJ-CW could activate thioglycollate broth-elicited macrophages and the peak of MTC was obtained with 10fig/ml of PJ-CW. When macrophages were treated with PJ-CW and macrophage-activating factor (MAP) ,the cytotoxic activity was significantly increased. The significance of regulation of MTC by PJ-CW in tumor immunity was briefly discussed.