摘要
目的 评价缬沙坦对高血压病患者血清Ⅲ型前胶原 (PCⅢ )水平及左室舒张功能的影响。方法 测定分析18例无左室肥厚的高血压病患者 (NLVH组 )、16例伴左室肥厚的高血压病患者 (LVH组 )缬沙坦治疗前、后血清PCⅢ水平及左室舒张功能指标的变化 ,并与 15例健康人 (正常对照组 )进行比较。分析血清PCⅢ水平与血浆血管紧张素Ⅱ (AngⅡ )的相关性。结果 二组高血压病患者血清PCⅢ水平均高于正常对照组 ,其增高程度与左室舒张功能指标E A比值呈显著负相关 (r =- 0 .82 5 7,P <0 .0 5 ) ,与血浆AngⅡ水平无明显相关性 (r =0 .336 2 ,P >0 .0 5 )。缬沙坦治疗后二组血压和血清PCⅢ水平均较治疗前显著降低 (P均 <0 .0 5 ) ,左室舒张功能指标E峰峰值增高、E A比值增大 (P <0 .0 5 ) ,A峰峰值降低 (P <0 .0 5 )。LVH组的左室重量指数 (LVMI)明显下降 (P <0 .0 5 )。结论 高血压病患者血清PCⅢ水平增高 ,左室舒张功能下降 ,缬沙坦可降低血清PCⅢ水平 ,改善左室舒张功能。
Objective To evaluate the effects of Valsartan on levels of serum pro-collagen Ⅲ (PCⅢ) and left ventricular diastolic function in patients with hypertension. Methods Levels of serum PCⅢ and left ventricular diastolic function were measured and analyzed in 18 hypertensive patients with left ventricular hypertrophy (group LVH) and 16 hypertensive patients without left ventricular hypertrophy (group NLVH) before and after Valsartan treatment for 12 weeks, and compared with 15 healthy persons (normal control group).The relationship between levels of serum PC Ⅲ and plasma angiotensinⅡ(AngⅡ) were analyzed. Results Levels of Serum PCⅢ in patients with hypertension (group LVH and group NLVH ) were increased than those of normal control group. An inverse correlation was found between levels of serum PCⅢ and E/A ratio (r=-0.8257,P<0.05),and no correlation between levels of serum PCⅢ and plasma AngⅡ(r=0.3362,P>0.05).Blood pressure,levels of serum PCⅢ and peak A velocity significantly decreased (P<0.05), peak E velocity and E/A ratio significantly increased (P<0.05) in patients with hypertension after Valsartan treatment for 12 weeks. LVMI in group LVH significantly decreased after treatment (P<0.05). Conclusion Levels of Serum PCⅢ are increased and left ventricular diastolic function decreases in patients with hypertension. Valsartan can decrease levels of Serum PCⅢ and improve left ventricular diastolic function.
出处
《中国心血管病研究》
CAS
2004年第12期944-947,共4页
Chinese Journal of Cardiovascular Research
