Ki-67和P21在肾上腺皮质癌中的表达及意义

The expression of Ki-67 and P21 in adrenocortical carcinoma and their significance

目的 探讨肾上腺皮质癌 (ACC)中Ki 67和P2 1的表达及其意义。方法 采用免疫组化SP法和图像分析技术对 8例正常肾上腺组织、2 0例肾上腺腺瘤 (ACA)、19例肾上腺皮质癌中Ki 67、P2 1进行检测。结果 Ki 67和P2 1的表达在肾上腺腺瘤与肾上腺皮质癌间差异均有统计学意义 (P <0 .0 1,P <0 .0 5 )。Ki 67的表达与肾上腺皮质癌分期、浸润或转移、2年生存情况相关(P <0 .0 1) ,与肿瘤大小无关 (P >0 .0 5 )。P2 1的表达与肾上腺皮质癌的大小、分期、浸润或转移、2年生存情况均无显著相关 (P >0 .0 5 )。结论 Ki 67和P2 1对肾上腺皮质良恶性肿瘤具有重要的鉴别诊断作用 ,Ki 67可作为判断肾上腺皮质癌预后不良的指标。

Objective To study the expression of Ki-67 and P21 in adrenocortical carcinoma and their significance.Methods Ki-67 and P21 were detected by immunohistochemical technique (SP method) and image analysis in 8 cases of normal adrenal,20 cases of adrenocortical adenoma (ACA) and 19 cases of adrenocortical carcinoma(ACC).Results There was statistically significant difference in expressions of Ki-67 and P21 among normal adrenal,adrenocortical adenoma and adrenocortical carcinoma(-P-<0.01,-P-<0.05).There was significant correlation between Ki-67 expression and tumor stage,invasion,metastasis,survival rate of 2 years (-P-<0.01).But there was no relationship between Ki-67 expression and tumor diameter (-P->0.05).There was no significant correlation between P21 expression and tumor diameter,stage,invasion,metastasis,survival rate of 2 years (-P->0.05).Conclusions Immunohistochemical assessment of Ki-67 and p21 can be useful in the differential diagnosis of adrenocortical adenoma and carcinoma.Ki-67 may be served as an unfavorable prognostic marker of adrenocortical carcinoma.