1～14岁正常小儿血清瘦素水平测定

Serum leptin concentrations in 1-14 year old healthy children

目的 研究 1～ 14岁正常小儿血清瘦素水平及其与性别、年龄、体质量指数 (BMI)的关系。方法 用免疫放射分析法测定 138例 1～ 14岁正常小儿的血清瘦素水平 ,分析其与性别、年龄的变化趋势 ,以及与BMI的相关性。结果 ①不同年龄组小儿血清瘦素水平测定值 ,1～ 5岁、>5～ 10岁、>10～ 14岁 3个年龄组男童分别为 (1.4 9± 0 .4 8) μg/L、(4.87± 3.5 1) μg/L、(3.34± 0 .85 ) μg/L ,女童分别为 (2 .12± 0 .4 7) μg/L、(7.6 9± 5 .84 ) μg/L、(12 .7± 5 .2 2 ) μg/L ,女童的血清瘦素水平随年龄增大而升高 ,男童 1～ 10岁 ,血清瘦素水平随年龄增大呈升高趋势 ,11～ 14岁 ,瘦素水平呈相反变化 ,即随年龄增大而降低 ;②相同年龄组女童的血清瘦素水平明显高于男童 (P <0 .0 1) ;③不论男童、女童 ,血清瘦素水平均与BMI呈显著正相关 (男r =0 .73,P <0 .0 0 1;女r =0 .81,P <0 .0 0 1)。结论 性别、年龄、BMI是影响小儿血清瘦素水平的 3个重要因素。

Objective To investigate the serum leptin concentration of children aged 1-14 years,and to analyze the relationship of serum leptin level with gender, age and body mass index(BMI) in children. Methods Serum leptin concentration was measured by immunoradiometric analysis in 138 healthy children (68 boys and 70 girls,age from 1 to 14 years). Results ① The serum leptin concentrations of boys in different age (1-5 y,6-10 y,11-14 y) were ( 1.49± 0.48) μg/L,( 4.87± 3.51) μg/L,( 3.34± 0.85) μg/L, and those of girls were ( 2.12± 0.47) μg/L,( 7.69± 5.84) μg/L,( 12.7± 5.22) μg/L. In girls the leptin levels increased with age. In boys leptin levels also tended to increase with age in subjects of 1-10 years of age, while drcreased in 11-14 years of age. ② In the same age group, the leptin levels of girls were higher than those of boys obviously. ③ In both boys and girls, serum leptin levels were significantly correlated positively with BMI(boys r= 0.73,P< 0.001;girls r= 0.81,P< 0.001). Conclusion Gender,age and BMI are the three major factors that affact the serum leptin concentrations of children.