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环氧化酶和多药耐药在肿瘤治疗中的研究及相互关系 被引量:1

Progress in the study of cyclooxygenase and MDR and their relationship in tumors therapy
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摘要 环氧化酶 (COX)是前列腺素合成过程中的关键酶 ,研究发现它参与肿瘤的发生发展 ,并在一定程度上影响肿瘤的转归 ,对多药耐药 (MDR)基因的调控是它影响肿瘤转归的重要因素。了解COX在肿瘤中的作用 ,明确COX和MDR在肿瘤中的关系 ,对肿瘤治疗具有重要意义。
出处 《国外医学(肿瘤学分册)》 CAS 2004年第12期895-898,共4页 Foreign Medical Sciences (Cancer Section)
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  • 1Tucker ON, Dannenberg AJ, Yang EK, et al. Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer. Cancer Res,1999,59 (5) :987-990.
  • 2Masferrer JL, Leahy KM, Koli AT, et al. Antiangiogenic and antitumor activities of cyclooxygenase -2 inhibitors. Cancer Res, 2000,60 ( 5 ):1306-1311.
  • 3Wun T, McKnight H, Tuscano JM. Increased cyclooxygenase-2 ( COX2 ) :a potential role in the pathogenesis of lymphoma. Leuk Res,2004,28(2) :179-190.
  • 4Goulet AC, Einsphar JG, Alberts DS, et al. Analysis of cyclooxygenase 2 ( COX-2 ) expression during malignant melanoma progression. Cancer Biol Ther,2003,2(6) :713-718.
  • 5Chen WS, Wei SJ, Liu JM, et al. Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2 )expression and inhibited by a COX-2-selective inhibitor, etodolac. Int J Cancer,2001,91 (6) :894-899.
  • 6Yao M,Lam EC,Kelly CR,et al. Cyclooxygenase-2 selective inhibition with NS-398 suppresses proliferation and invasiveness and delays liver metastasis in colorectal cancer. Br J Cancer,2004,90 ( 3 ) :712-719.
  • 7Sheng H,Shao J,Morrow JD,et al. Modulation of apoptosis and Bcl-2expression by prostaglandin E2 in human colon cancer cells. Cancer Res,1998,58(2) :362-366.
  • 8Cianchi F, Cortesini C, Bechi P, et al. Up-regulation of cyclooxygenase 2 gene expression correlates with tumor angiogenesis in human colorectal cancer. Gastroenterology,2001,121 (6) :1339-1347.
  • 9Marzolini C ,Paus E, Buclin T, et al Polymorphisms in human MDR1 (P-glycoprotein) :recent advances and clinical relevance. Clin Pharmacol Ther,2004,75 ( 1 ) :13-33.
  • 10Swannie HC,Kaye SB. Protein kinase C inhibitors. Curr Oncol Rep,2002,4( 1 ) :37-46.

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