丝裂霉素C在斜视术中应用的实验和临床观察

Clinical observation of mitomycin C in animal strabismus surgery

目的 探讨丝裂霉素C对斜视手术疗效的影响。方法 动物 (家兔 )组分丝裂霉素C组和对照组 ,手术后 1周和 4周取眼肌及周围组织做病理学检查。临床组 3 4例斜视手术中应用丝裂霉素C棉片贴敷后缝合切口。结果 动物组中 1周切片镜检丝裂霉素C组和对照组均为红细胞、炎性细胞和少量成纤维细胞 ,4周后镜检丝裂霉素C组成纤维细胞和新生血管明显少于对照组。临床组手术均一期愈合 ,眼球运动正常 ,无不良反应。结论 斜视手术应用丝裂霉素C具有明显的抑制成纤维细胞形成和新生血管的作用 ,且不影响手术切口的愈合 ,无并发症的产生。

Objective To investigate the effectiveness of mitomycin C in strabismus treatment.Methods Animals were divided into mitomycin C group and control group.1 week and 4 weeks post-operatively,peripheral tissues were removed to do pathological study.Results One week post operatively,animal tissue showed red cells,inflammatory cells and fibroblasts.4 weeks post operatively,fibroblasts and neovascular vessels in Mitomycin C group were apparently lower than that control group.Conclusion Mitomycin C can apparently inhibit the formation of fibroblast and new vessel.