胃癌与遗传

Gastric Cancer and Genetics

胃癌的遗传分两种形式,一种为家族性遗传模式(即强易感性),另一种为人群基础的遗传模式(即弱易感性)。胃癌发生与癌基因激活和肿瘤抑制基因失活有关,但并非是两者的简单综合体。胃癌转移和预后也明显受患者遗传背景的影响,如E鄄cadherin、基质金属蛋白酶等。胃癌与遗传(基因)学研究是一个系统的、全面的过程,单个基因、单个通路难以解释癌症复杂的生物学行为。

The genetics of gastric cancer commonly has two types:familial pattern (considered as strong susceptibility);and population-based pattern (considered as weak susceptibility).Development of gastric carcinoma is related to activation of oncogene and inhibition of tumor suppressive gene (TSG),however,it is not a simple complex of oncogene and TSG.Metastasis and prognosis of gastric cancer also are influenced by genetic factors, such as E-cadherin,matrix metalloproteinases and so on.The relationship between gastric cancer and genetics is a complicated and comprehensive system.The mechanism is not underlain in single gene or pathway.