更昔洛韦治疗婴幼儿秋季腹泻50例临床分析

A Clinical Study on Ganciclovir in Treating Autumn Diarrhea

目的 探索应用常规剂量更昔洛韦治疗婴幼儿秋季腹泻的确切疗效和临床安全性。方法 应用常规剂量更昔洛韦 (每日 5～ 1 0mg/kg ,连续 3～ 5d)治疗婴幼儿秋季腹泻 5 0例 ,观察有效率、显效时间和不良反应。以利巴韦林治疗的 30例作为疗效对照组。结果 治疗组 5 0例中 :痊愈 35例 (70 .0 %) ,显效 1 3例 (2 6 .0 %) ,总有效率达96 .0 %,总有效率和显效率均明显高于对照组 ,差别具有统计学意义。有效病例多数在治疗后 4 8h内明显见效 ,未见外周血白细胞和血小板下降 ,以及肝肾功能损害等明显不良反应。结论 应用常规剂量更昔洛韦治疗婴幼儿秋季腹泻的疗效确切 ,临床安全性好。在目前尚无明确的针对轮状病毒所致婴幼儿秋季腹泻抗病毒药物的情况下 ,值得临床谨慎推荐使用。

Objective To explore the effect and clinical safety on ganciclovir at routine dosage in treating autumn dirarrhea.Methods Fifty infants diagnosed as autumn diarrhea were applied gancicovir at routine dosage (5～10 mg/kg·d three to five days) and its effective rate effective time and side effect were studied.Results In the treatment group,35 cases (70.0%) were cured,13 cases (26.0%) got marked effectiveness and the total effective rate was 96.0%.The total effective and marked effective rate of the treatment group was higher than that of the control group.The difference was significant.Effective time was 48 hours after applying ganciclovir.And there was no side effects e.g. white cells and platelets reductioon;impairment of liver or kidney function.Conclusion The effects of routine dosage gancicovir treating autumn diarrhea are reliable and safe.There is no specific anti-rotavirus drugs at present so ganciclovir is recommended for treatment of autumn dirarrhea in infants.