CD117与CD34在胃肠道间质瘤中的表达及意义

EXPRESSION OF CD117(C-KIT PROTEIN) AND CD34 IN GASTROINTESTINAL STROMAL TUMORS(GIST) AND IT'S SIGNIFICANCE

目的 :探讨 CD1 1 7及 CD34在胃肠道间质瘤 (Gastrointestinal stromal tum or,GIST)中的诊断价值及其意义。方法 :应用免疫组织化学技术 SP法检测 6 5例 GIST中的 CD1 1 7与 CD34的表达情况 ,并与胃肠道和软组织的平滑肌瘤、雪旺瘤进行对照性研究。结果 :GIST中的 CD1 1 7阳性表达率为 92 % (6 0 / 6 5 ) ,CD34阳性表达率为 72 % (4 7/ 6 5 ) ,良性、潜在恶性和恶性GIST的 CD1 1 7和 CD34的表达水平差异无统计学意义 (CD1 1 7:χ2 =1 .1 5 7,P >0 .0 5 ;CD34:χ2 =1 .2 1 6 ,P >0 .0 5 )。胃肠道和软组织平滑肌瘤和雪旺瘤 CD1 1 7与 CD34均阴性表达。结论 :CD1 1 7是胃肠道间质瘤特异而敏感的标记物 ,CD34亦可作为GIST一个较好的标记物 ,两者联合使用可提高 GIST的检出率 ,但 CD1 1 7和 CD34均不能作为

Objective:To investigate the clinicopathological and prognostic significance of CD117(c kit protein) and CD34 in gastrointestinal stromal tumors(GIST).Methods:65 case GIST were analyzed for CD117 and CD34 expression by immunohistochemical method, while using leiomymas and schwannomas controls.Result:Of 65 GISTs, 92%(60/65)were positive for CD117 and 72%(47/65) were positive for CD34. Expression rate of CD117(χ 2=1 157,P>0 05) and CD34(χ 2=1 216,P>0 05) were not significantly different in the three patterns of GIST. Leiomyomas and schwannomas were typically CD117 and CD34 negative Conclusion:CD117 seems to be the most useful antibody in the diagnosis and differential diagnosis of GIST. CD34 was an important marker of GIST as well. A higher rate of diagnosis in GIST can be available by using both CD117 and CD34. But, CD117 and CD34 may not be used as a prognostic index.