鼻咽癌患者血清sICAM-1、sFas及sFasL的表达及其意义

EXPRESSION AND SIGNIFICANCE OF SERUM sICAM-1 AND sFas&sFasL IN PATIENTS WITH NASOPHARYNGEAL CARCINOMA

目的 :探讨鼻咽癌患者的血清可溶性 ICAM- 1 (s ICAM- 1 )、可溶性 Fas(s Fas)和可溶性 Fas L (s Fas L )表达及其意义。方法 :用酶联免疫吸附法 (EL ISA)检测 5 6例鼻咽癌患者 (鼻咽癌组 )和 2 1例正常人 (对照组 )的血清 s ICAM- 1、s Fas和 s Fas L水平。结果 :鼻咽癌组血清的 s ICAM- 1、s Fas和 s Fas L含量均明显高于对照组 (P <0 .0 1 ) ; 期和 期的鼻咽癌患者的血清s ICAM- 1、s Fas和 s Fas L含量均明显高于 、 期患者 (P <0 .0 1 ) ,而 期患者又明显高于 期患者 (P <0 .0 1 )。结论 :鼻咽癌存在与 s ICAM- 1、s Fas和 s Fas L表达相关的细胞免疫应答异常 。

Objective:To study the expression of serum sICAM 1 and sFas & sFasL antigens in patients with nasopharyngeal carcinoma and clinical significances.Methods:Enzyme linked immunosorbent assays(ELISA) was available to detect the expression of serum sICAM 1 and sFas & sFasL in 56 patients with nasopharyngeal carcinoma (NPC group)and 21 normal control subjects(normal group).Result:Expression of serum sICAM 1 and sFas & sFasL in NPC group were significantly higher than those of the normal group(P<0 01). Expression of serum sICAM 1 and sFas & sFasL in patients with NPC in the setting of Ⅲ or Ⅳ stage were significantly higher than those of patients in the setting of Ⅰ and Ⅱ stage(P<0 01), and expression of serum sICAM 1 and sFas & sFasL in patients with NPC in the setting of Ⅳ stage were significantly higher than those of patients in the setting of Ⅲ stage(P<0 01).Conclusion:sICAM 1 and sFas & sFasL might be involved in the cellular immunopathogenesis of nasopharyngeal carcinoma, and the measurement of the serum sICAM 1 and sFas & sFasL may reflect ability of neoplasm cell in freedom from host immunological surveillance. Dynamic measurement of serum sICAM 1 and sFas & sFasL may be a useful objective index to evaluate prognosis of nasopharyngeal carcinoma.