5Sehgal SN. Rapamune ( RAPA, rapamycin, sirolimus ):Mechanism of action, immunosuppressive effect results from blockade of signal transduction and inhibition cell cycle progression. Clin Biochem, 1998,31(5): 335-340.
6Panwalkar A, Verstovsek S, Giles FJ. Mammalian target of rapamycin inhibition as therapy for hematoligic malignancies.Cancer, 2004,100(4):657-666.
7Kaplan MJ, Ellis CN, Beta-Csorgo Z, et al. Sytemic toxicity following administration of sirolimus (formly rapamycin ) for psoriasis. Arch Dematol, 1999, 135(5):553-557.
8Guba M, Yezhelyev M, Eichhorn ME, et al. Rapamycin induces tumor-specific-thrombosis via tissue factor in the presence of VEGF. Blood, 2005,105(11):4463-4469.
9Battaglia M, Stabilini A, and Roncarolo M-G. Rapamycin selectively expands CD4 +/CD25+ FoxP3 + regulatory T cells.Blood, 2005, 105(12): 4743-4748.
10Murgia MG, Jordan S, Kahan BD. The side effect profile of sirolimus: a phase Ⅰ study in quiescent cyclosporine prednisone-treated renal transplant patients. Kidney Intern, 1996, 49(1):209-216.
