妊高征患者血清IL-1β及瘦素水平变化的研究

Study of IL-1β and leptin in pregnancy-induced hypertension women

目的 :研究中、重度妊娠高血压综合征 (妊高征 )患者孕晚期血清内瘦素及白介素 1- β(IL- 1β)水平的变化。方法 :应用免疫放射及放射免疫法检测 35例妊高征患者 (中度组 15例 ,重度组 2 0例 )和 35例年龄、孕前体质指数 (BMI)及孕周与其相匹配的血压正常的孕妇 (对照组 )血清瘦素及 IL- 1β水平。结果 :妊高征患者血清内瘦素水平 :中度为 (34.79± 2 .0 8) ng/ml,重度为 (4 2 .19± 2 .2 0 ) ng/m l,较对照组 (2 5 .2 8± 1.98) ng/m l明显升高 (P<0 .0 1) ,IL - 1β水平 3组无差异 (P>0 .0 5 ) ,分别为 (0 .11± 0 .0 4 ) ng/ml(正常 )、(0 .19± 0 .0 3) ng/ml(中度妊高征 )、(0 .13± 0 .0 4 ) ng/ml(重度妊高征 ) ,瘦素及 IL - 1β的水平不具有相关性。结论 :妊高征患者血清瘦素水平较对照组明显升高 ,且重度妊高征组血清瘦素浓度显著高于中度妊高征组 ,而 IL- 1β水平 3组无差异且与瘦素无相关。

Objective:To determin whether the maternal serum levels of leptin and interleukin 1β(IL-1β) are higher in mild,severe preeclamptic woman than in matched normal controle subjects in the third trimester,and to explore the correlation between leptin and IL-1β and their effects in PIH.Methods: The maternal serumleptin and IL-1β were respectively measured by immunoradiometric assay and radioimmunoassay in 35 preeclamptic woman (15 mild and 20 severe) and 35 normal pregnant women,matched for maternal age,prepregnancy body mass index and gestational age at sampling. Results:The maternal leptin concentrations were significantly higer(P<0.01) in women with PIH than in normal pregnant women(25.28±1.98)ng/ml.The serum leptin levels in the severe PIH group(42.19±2.20)ng/ml were elevated significantly(P<0.01) compared with mild PIH group(34.79±2.08)ng/ml.The maternal IL-1β were not different significantly in three groups:(0.11±0.04)ng/ml(normal),(0.19±0.03)ng/ml(mild PE),(0.13±0.04)ng/ml (severe PE). Matermal leptin and IL-1β did not correlated significantly. Conclusion:The leptin levels in PIH are higer than in that normal pregnancy,the leptin may play a role in the pathogenesis of PIH and related to the severity of PIH .In PIH, the leptin levels isn't related to IL-1β.