胰腺癌中凋亡抑制基因的表达意义

Expression of Survivin in Pancreatic Adenocarcinoma and Its Value

目的 探讨凋亡抑制基因 (survivin)在胰腺癌中的表达及其与临床病理特征的关系。方法 应用免疫组织化学链霉菌抗生物素 -过氧化酶连接法 (SP法 )检测survivin的表达情况。结果 胰腺癌中survivin阳性表达率为 87.88% ,高于 12例正常胰腺组织 (41.6 7% )具有差异性 (P <0 .0 5 ) ;而 10例良性胰腺疾病组织中均为阴性表达 ,与癌组织比较 ,具有差异性 (P <0 .0 5 ) ,且survivin与胰腺癌病理分级、TNM分期及淋巴结转移情况无关。结论 survivin在胰腺癌中的高表达提示其可能与肿瘤的发生有关 ,是胰腺癌早期而普遍的事件 ,有望成为一新的肿瘤标志物应用于临床 ,协助胰腺癌早期诊断和靶向性治疗。

Objective To investigate the expression of survivin in pancreatic cancer and its relation to clinicopathological characteristics. Methods The expression of survivin were evaluated with immunohistochemistry of SP method. Results The positive rate of survivin in pancreatic cancers was 87.88%, obviously higher than that of weak expression detected in 12 cases adjacent normal tissues ( 41.67%)(P< 0.05). Whereas survivin was undetectable in the 10 benign diseases. Compared with the tumors, there was significant difference (P< 0.05). Besides, the expression of survivin was not related with the pathological characters and TNM stage of pancreatic cancer.Conclusion The excessive expression of survivin could be not only correlated with the occurrence of carcinoma but also an early and common thing in pancreatic carcinogenesis. So it'll promisingly become a new tumor marker and will be applied in the clinical practice helping the earlier diagnosis as well as targeting gene therapy for pancreatic cancer.