乳腺癌中P73、P21的表达及其意义

EXPRESSION AND SIGNIFICANCE OF P73 AND P21 IN BREAST CARCINOMA

目的 :通过检测 P73蛋白、P2 1蛋白在乳腺癌中的表达及其与临床病理指标的关系 ,探讨乳腺癌的生物学特性 ,分析它们在乳腺癌的发生、转移中所起的作用。方法 :应用免疫组化 S-P法检测 68例乳腺癌石蜡包埋标本中 P73、P2 1的表达情况。结果 :a.在乳腺癌 - 级与 级之间 P73蛋白阳性率分别为 1 8.75 % ( 9/48)和 60 .0 0 % ( 1 2 /2 0 ) ,差异有显著性 ( P <0 .0 5 )。随着 P73阳性表达率增高 ,乳腺癌的恶性程度增高。b.淋巴结转移组 p2 1的阳性表达率 2 3 .3 3 % ( 7/3 0 )明显低于无淋巴结转移组的阳性率 5 2 .63 % ( 2 0 /3 8) ,差异有显著性( P <0 .0 5 )。c.P73、P2 1之间无相关。结论 :P73、P2 1与乳腺癌的发生。

Objective: To investigate the biological features of breast carcinoma and analyze P73 and P21's functions in progression and metastasis of breast carcinoma by the examination of P73, P21 and their relationship with clinicopathological index. Methods: A total of 68 paraffin-embedded tissue of breast carcinomas were observed by the use of S-P method to examine the expression of P73, P21 proteins. Results: (1)The postive expression rate was 18.75%(9/48) and 60.00% (12/20) in grade Ⅰ-Ⅱ and grade Ⅲ of breast carcinoma respectively, with significant difference ($P$<0.05). Breast tumor malignant degree increased with P73 positive expression increased. (2)The postive expression rate of P21 in the group with lymph nodes metastasis was 23.33%(7/30), that of P21 in non-lymph nodes metastasis was 52.63%(20/38). the former was lower than the latter, with significant difference (P<0.05). (3)There were no significant correlations between P73 and P21. Conclusion: It revealed that P21 and P73 were correlated with the genesis and progression of breast carcinomas.