生长抑素类似物在增殖性玻璃体视网膜疾病中的应用及研究进展

Application and studying prog-ress of somatostatin analogue in prolifera tive retinopathy

增殖性玻璃体视网膜疾病是全世界范围内引起视力丧失的最主要原因之一 ,目前已认可的治疗方法包括全视网膜光凝和冷冻疗法 ,这些治疗方法对视网膜会造成一定的损害。视网膜疾病尤其是增殖性糖尿病视网膜疾病的药物治疗学方面的研究如合成的生长抑素类似物的应用是一个有前景的研究领域。目前已试用长效生长抑素类似物治疗糖尿病性视网膜疾病 ,这种治疗方法是否对视网膜新生血管性疾病如早产儿视网膜疾病、老年性黄斑病变等有效 ,仍需要进一步研究。我们就生长抑素的研究概况。

Proliferative retinopathies account for the majority of cases of v ision loss throughout the world.Currently accepted therapy for retinopathy cons ists of retinal ablation by panretinal laser photocoagulation or cryotherapy. Th is technique is not without deleterious effects to patients, including diminishe d night vision, reduced peripheral vision and loss of precise vision, decreasing visual acuity by one to two lines in magnitude. One promising area of research into pharmacotherapeutics for retinopathies, espe cially proliferative diabetic retinopathy, involves the use of synthetic analogu es of somatostatin. Whether such a therapy may also prove effective for other re tinal vascular proliferative diseases such as retinopathy of prematurity and age -related macular degeneration remains an open question that deserves attention.