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色素上皮衍生因子与眼部新生血管性疾病 被引量：2

Pigment epithelium-derived factor and angiogenesis diseases in the eyes
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摘要 色素上皮衍生因子 (pigmentepithelium derivedfac tor ,PEDF)主要来源于眼部的色素上皮细胞 ,具有抗血管新生和神经营养的双重功效。最早是由胎儿视网膜色素上皮细胞的培养液中分离出来的。目前研究认为PEDF是最有效的内源性眼部新生血管抑制剂 ,对新生血管的形成起着重要的调控作用。我们就PEDF的生物学特性、表达部位、调节机制、抗血管新生的作用机理以及PEDF与眼部新生血管性疾病的研究进展作一综述。 Pigment epithelium-derived factor (PEDF) is mainly derived from pig ment epithelial cells in eyes, which possesses dual functions (anti-angiogenic and neurotrophic activities).It was first isolated from medium conditioned by hu man fetal retinal pigment epithelial cells.PEDF has recently been shown to be t he most potent endogenous inhibitor of angiogenesis in the eyes.It plays an imp ortant role in controlling of vascularization. This review is focused on the bio logical characteristics,expression sites,mechanism of modulation and antiangio genic activity,and the advances of PEDF and angiogenesis diseases in the eyes. 
作者 张雷 王康孙
机构地区 上海第二医科大学附属瑞金医院眼科
出处 《眼科新进展》 CAS 2004年第6期501-503,共3页 Recent Advances in Ophthalmology
关键词 色素上皮衍生因子 新生血管 神经营养 pigment epithelium-derived factor angiogenes is neurotrophic
分类号 R774.1 [医药卫生—眼科]
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参考文献22

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同被引文献19

  • 1张鹏,王雨生,惠延年,白建伟,胡丹.缺氧诱导因子1与眼内新生血管[J].眼科新进展,2004,24(3):224-226. 被引量：11
  • 2刘静,关明,Cheung Kin-Fai.色素上皮细胞衍生因子在眼科中的作用(英文)[J].国际眼科杂志,2004,4(3):397-403. 被引量：5
  • 3雷春涛,张学东,方静,李琦,周善璧.奥曲肽抑制小鼠视网膜新生血管形成的研究[J].眼科研究,2004,22(6):623-625. 被引量：11
  • 4Philipp W,Speicher L,Humpel C.Expression of vascular endothelial growth factor and its receptors in inflamed and vascularized human corneas[J].Invest Ophthalmol Vis Sci 2000;41(9):2514-2522.
  • 5Kwak N,Okamoto N,Wood JM,Campochiaro PA.VEGF is major stimulator in model of choroidal neovascularization[J].Invest Ophthalmol Vis Sci 2000;41(10):3158-3164.
  • 6Shao C,Sima J,Zhang SX,Jin J,Reinach P,Wang Z,et al.Suppression of corneal neovascularization by PEDF release from human amniotic membranes[J].Invest Ophthalmol Vis Sci 2004;45(6):1758-1762.
  • 7Bouck N.PEDF:anti-angiogenic guardian of ocular function[J].Trends Mol Med 2002;8(7):330-334.
  • 8Volpert OV,Zaichuk T,Zhou W,Reiher F,Ferguson TA,Stuart PM,et al.Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor[J].Nat Med 2002;8(4):349-357.
  • 9Liu H,Ren JG,Cooper WL,Hawkins CE,Cowan MR,Tong PY.Identification of the antivasopermeability effect of pigment epithelium-derived factor and its active site[J].Proc Natl Acad Sci USA 2004;101(17):6605-6610.
  • 10Bouck N.PEDF:anti-angiogenic guardian of ocular function[J].Trends Mol Med 2002;8(7):330-334.

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眼科新进展
2004年 第6期

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