艾灸抗炎免疫作用及对神经递质影响的实验研究

Experimental study on effects of moxibustion's anti inflammatory and immunity action on neurotransmitter

目的 :探讨灸法治疗 RA抗炎免疫作用的中枢神经递质调控机理。方法 :建立 AA大鼠模型 ,观察艾灸肾俞穴对炎症肿胀、细胞因子 IL- 6、IL- 2以及下丘脑内神经递质 NE、5- HT和 NO的影响。结果 :1 .灸治 AA大鼠能减轻炎症肿胀 ,降低 IL- 6,提高 IL- 2 ,与对照组比较差异显著 ( P<0 .0 1 ) ,表明灸疗能抗炎消肿 ,抑制炎症因子 ,提高机体免疫功能 ;2 .灸疗能上调 NE、5- HT的水平 ,降低 NO的含量 ,提示艾灸能激活或调整 HPA轴抗炎免疫的功能活动 ,有利于 AA的缓解与转归。结论 :艾灸有抗炎免疫的作用 ,下丘脑神经递质参与对该作用的中枢调节。

Object:It were to study the effect on the central neurotransmitter of moxibution when it were used to treat rheumatoid arthritis,so as to determine the mechanism of anti inflammatory and immunity action of moxibution.Method:adjuvant arthritis models in rats were made,and the degree of inflammatory swelling,IL-6,IL-2 and NE,5-HT,NO in hypothalamus after moxibustion on point“Shen Shu” were measured.Result:1.Treatment of moxibustion alleviated the swelling,reduced IL-6 and increased IL-2(P<0.01,comparing with control group),indicating that moxibustion can relieve inflammation,restrain the forming of inflammatory factors and raise the immunity of body.2.Treatment of moxibustion elevated the level of NE,5-HT,and brought down the level of NO,indicating that moxibustion can activate or regulate the anti inflammatory and immunity function of HPA axis,and help relieve adjuvant arthritis.Conclusion:Moxibustion has the effect of anti inflammation and immunity,and hypothalamic neurotransmitters may take part in its action of central regulating.