超声促透对丹参膜中丹参素透过量的影响

Ultrasound Affecting to Danshensu Penetrating Content in the Film of Chinese Materia Medica

以 HPLC方法测定丹参素的透过量 ,以 L9(3) 4正交实验设计安排超声及其他因素对丹参素透过量影响的筛选实验。结果显示不同的超声强度、促透剂的不同品种、EVA的加入量以及透过温度 ,均对丹参素的透过量产生影响。EVA的加入量越大透过量越少 ,而超声促透能明显增加透过量 ,其中 1 0 0 A的超声促透条件最佳。

According to the penetrating content indexes of danshensu determined by HPLC method the ultrasound effective was studied with orthogonal test.results show that the excellent factors and levels are 100A ultrasound at 37℃ adding to DMSO and not using EVA.